Prenatal Genetic Screening And Diagnosis PGS/PGD

 

Q: WHAT IS IVF WITH PGD, OR PREIMPLANTATION GENETIC TESTING AND PGS OR PREIMPLANTATION GENETIC SCREENING?

  • PGD, preimplantation genetic diagnosis, involves removing a cell from an IVF embryo to test it for a specific genetic condition (thalassemia major, cystic fibrosis, for example) before transferring the embryo to the uterus.
  • PGS, preimplantation genetic screening, is the term for testing for overall chromosomal normalcy in embryos. PGS is not looking for a specific disease diagnosis – it is screening the embryo for normal chromosome number

Q: WHO MIGHT BENEFIT FROM IVF WITH PGD?

In general, there are 5 main groups of patients that might utilize PGS or PGD (list is not exhaustive)   Patients that are having IVF with advanced female age – 38 or older (common) in general, about 30-60% of human embryos have some type of chromosomal abnormality. This increases significantly with advancing female age

  • Patients that are having IVF with advanced female age – 38 or older (common) in general, about 30-60% of human embryos have some type of chromosomal abnormality. This increases significantly with advancing female age .
  • Patients of any age with repeated IVF failure – usually defined as 3 or more failed attempts .
  • To screen for inherited genetic diseases like thalassemia, cystic fibrosis and many more disease etc. In such a scenario, PGD can clearly benefit the couple. For example, if the male partner and female partner are both carriers of a recessive disease (such as thalassemia, cystic fibrosis etc), their child (conceived naturally) would have a 25% chance of having severe form of this disease. By having IVF and PGD, they can have “normal” embryos transferred so that (if IVF is successful) their child should not have cystic fi
  • Patients that are carriers of chromosomal translocations. These embryos are at very high risk for miscarriage or could result in the birth of a child with birth defects. This is another situation where PGS can help. By having IVF aneuploidy screening of the embryos, they can have chromosomally normal embryos transferred. This greatly reduces their risk for miscarriage and birth defects.
  • Patients that have had recurrent miscarriages

Q: AT WHAT DIFFERENT STAGES OF DEVELOPMENT CAN AN EMBRYO  BE BIOPSIED ?

Q: WHICH ARE THE BEST PGD CLINICS?

  • In general, the best clinics for PGD or PGS will be the clinics with the best IVF success rates.
  • It is critical to have an excellent culture system in order to get a maximal number of quality blastocysts for biopsy.
  • Also, the skills of the embryologist are of utmost importance to carry out such procedures.
  • Very few centres in India carry out procedures of IVF with PGS/PGD due to extreme precision required for this procedure.

EGG DONOR (OOCYTE DONOR)

Egg donor program is part of IVF where in the oocytes (eggs) of an egg donor are utilized to fertilize with husbands sperms and transferred in patients uterine cavity to achieve pregnancy.

IVF WITH OOCYTE DONOR IS LEGAL IN INDIA

Who needs donor oocytes :

  • Patients with premature ovarian failure
  • Poor responders in IVF failing to produce good number of eggs
  • Repeated IVF failure where poor embryos form resulting from poor oocyte quality
  • Known genetic defect in female partner and couple not opting for preimplantation genetic testing on embryos.

HOW WILL OOCYTE DONORS BE SELECTED ?

  • Oocyte donors are recruited through oocyte donor agency.
  • After detailed history taking and physical examination donors are screened and necessary blood test are performed including AMH (ovarian reserve test)thalassemia screen and infectious markers (HIV, HBsAg, anti HCV and VDRL) .
  • Once they are found to be suitable, their profile (except their photographs/identity) would be sent to you .
  • The ovarian stimulation and monitoring for egg donors is the same as for any patients undergoing IVF.

 

She is not merely a brilliant doctor but she is also a genuine, honest and compassionate human being which is the differentiator between a good doctor and a great one. Strongly recommended.

Shikha Misra

Shikha Misra

4th Avenue

Thanks for Ur love,care n support throughout in my pregnancy. Even I was remembering Ur motherly care at the time of delivery also. U hv been an angel to have me my second child happily n healthily.

Khusboo Arora

Khusboo Arora

12 Main Road

Dr. Shweta Mittal Gupta, a doctor par excellence, a great orator, a wonderful human being and above all my inspiration, my mentor. May God bless her in all her endeavours.

Raman Singla

Raman Singla

23rd Street

Dr.Shweta has been a ray of light in our lives helping us to have the most beautiful gift of life in the form of our baby. Her knowledge and expertise in her field is significant. Apart from being a remarkable gynecologist, she is a wonderful human being supporting her patients with utmost care. I highly recommend Dr.Shweta and her support team.

Swati Shankdhar

Swati Shankdhar

Dr. Shweta Mittal has been really helpful throughout my pregnancy and always there a call away. My sister in law referred me here and I am really satisfied with the care and help she offers. She is really supportive and explains everything nicely whatever we asked her.

Sonam Arya

Sonam Arya

Hi, we are grateful to Dr.Shweta, the whole team works like a good and competent team under the guidance of Dr.Shweta and above all, I always say to her whenever I meet her that “I Love You” my deepest regards to her. I am blessed with a baby girl and wish that one day she will also be Competent, commanding, intelligent and successful like ma’am, thanks to ma’am and every team member.

 Amit Mutreja

 Amit Mutreja

Dr. Shweta Mittal Gupta, a doctor par excellence, a great orator, a wonderful human being and above all my inspiration, my mentor. May God bless her in all her endeavours.

Shubhi Arora

Shubhi Arora

Our journey start from Oct 2018 with Dr shweta Mittal in Sir Ganga Ram hospital. On First met we were get insure that Dr.Shweta Mittal is the only Doctor Who make us happy to get parents. She is very good in nature, soft-spoken, kind hearted person. Now we get a healthy baby by the grace of God and with the bless of Dr Shweta Mittal

Ravi Aggarwal

Ravi Aggarwal

After 6 years of marriage and while we were missing the presence of a child in our life. We were referred by a close friend of us. Who herself was a patient of Dr. Shweta Mittal. Dr. Shweta turned out to be the Angel we were searching for and within 2 months the good news was there.

Balaji Kumar

Balaji Kumar

We had a great experience with Dr. Shweta Mittal Gupta. Her clinical sense, experience and expertise has made us proud parents today. She has guided us very well before and throughtout the pregnancy. Thanks alot ma’m.High regards.

Amit Kumar

Amit Kumar

Shewta Mittal Gupta is a great doctor.She has provided us best treatment.Formulated very good strategy which one was very benefical in long term and in contigency for us.Today we blessed with baby boy just because of Doctor Shewta Mittal Gupta.For us Doctor Shewta Mittal Gupta is the best.She did miracle for us.

Ravi Kumar

Ravi Kumar

Dr Shweta Mittal is a blessing for us, we have met her last year after reading reviews and thats when we figured out that we are in right hands, she listened to us and gave us the comfort we needed. She is very soft spoken and she explains everything in detail where a layman could understand complex procedures of medicine.

DIGVIJAI TRIPATHI

DIGVIJAI TRIPATHI

A very wonderful and an amazing experience I have with my doctor (Dr. Shweta Mittal Gupta) who has given me the best gift of motherhood. Her positive attitude towards the condition of an IVF patient is just unexplainable. Her only word which I had heard from her mouth was (then what)always gave me the positive energy for handling my nine months of pregnancy.

Garima Chhabra

Garima Chhabra

My heartiest and biggest Thanks to Dr Dr shweta mittal ma’am. She vaid for making my journey completely of parenthood. After 7 years of marriage and struggle for parenthood Now I bless to enter motherhood. Just because of Dr shweta mittal ma’am and her advance and Hi_technology I will always be obligated to Dr shweta mittal.

Preeti Khattar

Preeti Khattar

I am very grateful to Dr Shweta Mittal that due to her IVF treatment and guidance, i am now mother of a baby girl. Earlier i was very disappointed but the type of guidance and treatment was given to me by Dr Shweta mittal..this miracle happens. Thankyou vey much doctor.

Shakeel Ahmed

Shakeel Ahmed

Dr. Shweta Mittal Maam is the number one IVF specialist in the country. She is the best most soft spoken out of the world and amazing Doctor of us. I will highly recommend Dr shweta mittal maam to everybody. Thank you so much Dr shweta mittal maam n her ivf team

Kabeer

Kabeer

Today i am very happy i blassed with a baby girl after marriage of 23 year just because of Dr Shweta mittal mam gudience & help.Our journey today complete.She always help in emergency satution she is very good listion .
Once again Thanku very much of Dr shweta Mittal mam & Her IVF team for supporting us every time.

Jeetyendra Negi

Jeetyendra Negi

Subscribe to My Newsletter


Private OPD

Mon-Sat, OPD No.F 45Time: 2-4 pmSir Ganga Ram HospitalRajinder Nagar, New Delhi-110060For appointment:011-42254000 ,011-42251800

Clinic: Unity Health Care clinic (UHC)

Mon - Sat (9 am - 6 pm)7/11, Ground Foor, East Patel Nagar,New Delhi110008For appointment: 8800443314

Teleconsultation & video consultation

Download app My follow up, doctor ID: 70Visit www.sgrh.com